2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-101172R
    RS 23597-190 (Standard) 149719-06-2 98%
    RS 23597-190 (Standard) is the analytical standard of RS 23597-190 (HY-101172). This product is intended for research and analytical applications. RS 23597-190 (EP-A-501322) is a high affinity and selective 5-HT4 receptor antagonist. RS 23597-190 inhibits Serotonin (HY-B1473A)-induced tachycardia. RS 23597-190 significantly inhibits superoxide production in high glucose.
    RS 23597-190 (Standard)
  • HY-101193R
    Zinc Protoporphyrin (Standard) 15442-64-5
    Zinc Protoporphyrin (Standard) is the analytical standard of Zinc Protoporphyrin. This product is intended for research and analytical applications. Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) is an orally active and competitive heme oxygenase-1 (HO-1) inhibitor and markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2. Zinc Protoporphyrin is used as a screening marker of iron deficiency in individual pregnant women and children, but also to assess population iron status in combination with haemoglobin concentration. Zinc Protoporphyrin has anti-cancer activity.
    Zinc Protoporphyrin (Standard)
  • HY-101232R
    Tiotidine (Standard) 69014-14-8
    Tiotidine (Standard) is the analytical standard of Tiotidine. This product is intended for research and analytical applications. Tiotidine (ICI 125211) is a potent and selective antagonist of histamine H2-receptor (pA2=7.3-7.8 for guinea-pig right atrium). Tiotidine has low affinity for both the H1 and the H3 receptors.
    Tiotidine (Standard)
  • HY-101237R
    DHBP dibromide (Standard) 6159-05-3 98%
    DHBP (dibromide) (Standard) is the analytical standard of DHBP (dibromide) (HY-101237). This product is intended for research and analytical applications. DHBP dibromide is an inhibitor for calcium release and a muscle relaxant.
    DHBP dibromide (Standard)
  • HY-101274A
    (3α,5β,6β,7α)-BAR501 1632118-70-7 98.0%
    (3α, 5β, 6β, 7α)-BAR501 (BAR504-6b) is a compound having cholane scaffolds of formula. (3α, 5β, 6β, 7α)-BAR501 can be used for the research of FXR and TGR5/GPBAR1 mediated diseases.
    (3α,5β,6β,7α)-BAR501
  • HY-101310R
    SYM 2081 (Standard) 31137-74-3 98%
    SYM 2081 (Standard) is the analytical standard of SYM 2081 (HY-101310). This product is intended for research and analytical applications. SYM 2081 is a kainate receptor agonist. SYM 2081 is a substrate of EAAT1 (Km of 54 μM). SYM 2081 inhibits EAAT2-mediated glutamate transport (Kb is 3.4 μM in Xenopus oocytes), modulates Apoptotic signaling pathways (increases Bcl-2 and decreases Bax/caspase-3 expression). SYM 2081 exhibits neuroprotective activity. SYM 2081 can be used in the study of hypoxic-ischemic brain damage and inflammatory or neuropathic pain.
    SYM 2081 (Standard)
  • HY-101312R
    Cilostamide (Standard) 68550-75-4 98%
    Cilostamide (Standard) is the analytical standard of Cilostamide. This product is intended for research and analytical applications. Cilostamide is a selective and potent PDE3 inhibitor, with IC50s of 27 nM and 50 nM for PDE3A and PDE3B, respectively, and has antithrombotic and anti-intimal hyperplastic activity.
    Cilostamide (Standard)
  • HY-101360R
    1-EBIO (Standard) 10045-45-1 98%
    1-EBIO (1-Ethyl-2-benzimidazolinone) (Standard) is the analytical standard of 1-EBIO (HY-101360). This product is intended for research and analytical applications. 1-EBIO is an activator of Ca2+ sensitive K+ channels wirh an EC50 of 136 μM for KCa3.1. 1-EBIO induces Cl- secretion, K+ conductance, membrane hyperpolarization, and afterhyperpolarisation currents. 1-EBIO reduces epileptiform activity, seizure incidence, and rescues cells from Ionomycin (HY-13434)-induced death.
    1-EBIO (Standard)
  • HY-101369R
    BW-723C86 (Standard) 160521-72-2 98%
    BW-723C86 (Standard) is the analytical standard of BW-723C86 (HY-101369). This product is intended for research and analytical applications. BW-723C86 is an orally active and a selective 5-HT2B receptor agonist. BW-723C86 exhibits anxiolytic-like actions. BW-723C86 also causes hyperphagia and reduced grooming in rats. BW-723C86 dilates pulmonary arteries and inhibits liquid meal-induced gastric accommodation.
    BW-723C86 (Standard)
  • HY-101385R
    L-765314 (Standard) 189349-50-6 98%
    L-765314 (Standard) is the analytical standard of L-765314 (HY-101385). This product is intended for research and analytical applications. L-765314 is a potent and selective α1b adrenergic receptor antagonist with Kis of 5.4 nM and 2.0 nM for rat and human α1b adrenergic receptor, respectively.
    L-765314 (Standard)
  • HY-101433R
    N-Acetylprocainamide hydrochloride (Standard) 34118-92-8 98%
    N-Acetylprocainamide (Acecainide) hydrochloride (Standard) is the analytical standard of N-Acetylprocainamide hydrochloride (HY-101433). This product is intended for research and analytical applications. N-Acetylprocainamide hydrochloride is a class III antiarrhythmic, which blocks K+ channels. N-Acetylprocainamide hydrochloride exerts inhibitory effects on the maximum following frequency (MFF) of isolated rabbit atria. N-Acetylprocainamide hydrochloride can be used for the study of arrhythmias.
    N-Acetylprocainamide hydrochloride (Standard)
  • HY-101529R
    Imanixil (Standard) 75689-93-9 98%
    Imanixil (Standard) is the analytical standard of Imanixil (HY-101529). This product is intended for research and analytical applications. Imanixil (HOE-402 free base) is an orally active LDL receptor (LDLR) inducer. Imanixil can reduce cholesterol levels by inhibiting VLDL-lipid production. Imanixil can delay atherosclerosis profession. Imanixil can be used for the research of cardiovascular disease, such as atherosclerosis.
    Imanixil (Standard)
  • HY-101644A
    Saterinone hydrochloride 102685-83-6 98%
    Saterinone hydrochloride is a phosphodiesterase III (PDE III) inhibitor.
    Saterinone hydrochloride
  • HY-101656A
    Medroxalol hydrochloride 70161-10-3 98%
    Medroxalol hydrochloride is an orally active adrenergic receptor antagonist, blocks α- and β-adrenergic receptors. Medroxalol hydrochloride shows antihypertensive and vasodilating effects.
    Medroxalol hydrochloride
  • HY-101656R
    Medroxalol (Standard) 56290-94-9 98%
    Medroxalol (Standard) is the analytical standard of Medroxalol (HY-101656). This product is intended for research and analytical applications. Medroxalol (RMI81968) is an orally active adrenergic receptor antagonist, blocks α- and β-adrenergic receptors. Medroxalol shows antihypertensive and vasodilating effects.
    Medroxalol (Standard)
  • HY-101682A
    SCH 42495 racemate 145841-10-7 98%
    SCH 42495 racemate is the racemate of SCH 42495. SCH 42495 is an orally active neutral metalloendopeptidase (NEP) inhibitor with antihypertensive effect. SCH 42495 is the orally active ethylester proagent of SCH 42354.
    SCH 42495 racemate
  • HY-101752A
    (±)-Befunolol hydrochloride 39543-79-8 98%
    (±)-Befunolol hydrochloride is a β-adrenoceptor blocking agent.
    (±)-Befunolol hydrochloride
  • HY-101761R
    TM5441 (Standard) 1190221-43-2 98%
    TM5441 (Standard) is the analytical standard of TM5441 (HY-101761). This product is intended for research and analytical applications. TM5441 is an orally bioavailable inhibitor of plasminogen activator inhibitor-1 (PAI-1), has IC50 values between 13.9 and 51.1 μM and induces intrinsic apoptosis in several human cancer cell lines. TM5441 attenuates Nω-nitro-l-arginine methyl ester-induced cardiac hypertension and vascular senescence.
    TM5441 (Standard)
  • HY-101823A
    A-81282 141872-46-0 98%
    A-81282 (Abbott 81282) is an antagonist of angiotensin II's AT1 receptor, with a pA2 value of 9.64 at the AT1 receptor in rabbit aorta. A-81282 also demonstrates significant inhibitory action on the binding of [125i]_Sar1_lle8_Angiotensin_ll to rat liver membranes, with a pKI value of 8.505. A-81282 has antihypertensive activity and can effectively lower blood pressure in renal artery-ligated rats.
    A-81282
  • HY-101832R
    SBC-110736 (Standard) 1629166-02-4 98%
    SBC-110736 (Standard) is the analytical standard of SBC-110736 (HY-101832). This product is intended for research and analytical applications. SBC-110736 is a proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor extracted from patent WO2014150395A1.
    SBC-110736 (Standard)
Cat. No. Product Name / Synonyms Application Reactivity